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KDM6B deficiency inhibits secretion of immunosuppressive mediators such as MAF BZIP transcription factor B (MAFB), suppressor of cytokine signaling 3 (SOCS3), and signal regulatory protein alpha (SIRPA), thereby enhancing the efficacy of anti-PD-1/programmed cell death 1 ligand 1 (PD-L1) therapy [52]

This gives the glutathione its antioxidizing power and be frequently called as the "master antioxidant"

Lactic acid is present as a lactate-conjugated base at a physiological pH of 7.4, and exists in two enantiomeric forms in mammals: L-lactate is produced during glycolysis when oxygen levels are low (3), while D-lactate is formed through the detoxification of methylglyoxal (2)

The qualified PCR products were used to construct sequencing libraries by TruSeq Nano DNA LT Library Prep Kit (Illumina, CA, United States)